When you are disobedient to God.

Deuteronomy 28:15-68 says that if you reject the Lord, he will bring disaster, confusion, and trouble in everything you do, until you are quickly and completely destroyed.

Disobedience can ruin the very person God wants us to be. Moreover, disobedience can inflict so much emotional pains on us to the extent that we become a slave to bitterness, anger, unforgiveness, and so forth. And mental consequences have to do with the fact that sin burdens the conscience of men.

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